When starting the Ozempic 1.34mg/ml (1mg/dose) Pre-filled Pen, some users may experience mild and temporary side effects as the body adapts to semaglutide. The most common reactions include nausea, vomiting, diarrhea, and decreased appetite. These symptoms often improve over time as treatment continues. In rare cases, patients may experience more serious issues like pancreatitis or allergic reactions, so medical guidance is essential. Drinking water regularly, eating smaller meals, and following the prescribed dosage schedule can help reduce discomfort. Most individuals tolerate the medication well, and its benefits in controlling blood sugar often outweigh initial gastrointestinal side effects.